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The biopharmaceutical industry in China: history and future perspectives

Kai Gao, Junzhi Wang

Frontiers of Medicine 2012, Volume 6, Issue 2, Pages 101-111 doi: 10.1007/s11684-012-0191-9

Abstract:

Biopharmaceuticals reflect the rapid progress achieved in modern biomedical research. This area has also become one of the main criteria for assessing the development level of biotechnology for a particular country. Although it has been only three decades since the first biopharmaceutical, recombinant human insulin, was licensed by the US Food and Drug Administration, the biopharmaceutical industry has become the fastest growing, most dynamic and technology-intensive sector in the biomedical field. Since the licensing of recombinant human interferon α1b in 1989, the biopharmaceutical industry in China has gone through initial developments and gradually entered a period of rapid growth. This paper provides an overview of the status and development trends of biopharmaceuticals in China, and compares them with those observed in developed countries.

Keywords： biopharmaceuticals antibodies market trends diseases China national regulatory agency

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The regulatory sciences for stem cell-based medicinal products

Bao-Zhu Yuan,Junzhi Wang

Frontiers of Medicine 2014, Volume 8, Issue 2, Pages 190-200 doi: 10.1007/s11684-014-0323-5

Abstract: Moreover, some stem cell-based products have been approved for marketing by different national regulatoryexist and need to be urgently addressed, especially in countries where establishment of appropriate regulatoryMore relevantly, the stem cell regulatory sciences need to be established or improved to more effectivelyevaluate quality, safety and efficacy of stem cell products, and for building up the appropriate regulatoryregulations, and the associated challenges, and we then propose some considerations for improving stem cell regulatory

Keywords： cell-based medicinal products (SCMPs) stem cell therapy (SCT) safety effectiveness standards guidelines regulatory

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Agency Costs of Engineering Procurement

Chen Shouke,Wei Zhuobin

Strategic Study of CAE 2005, Volume 7, Issue 11, Pages 66-71

Abstract: game and principal-agent theory, by analyzing the forming reasons and connotation relationships of agency

Keywords： engineering procurement agency cost asymmetric information game principal-agent theory

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Zero E-waste: Regulatory impediments and blockchain imperatives

Mengjun Chen, Oladele A. Ogunseitan

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 6, doi: 10.1007/s11783-021-1402-x

Abstract: Increasingly, 3re implementation is restricted by regulatory difficulties, particularly the invocation

Keywords： Blockchain E-waste Regulatory Policy Copyright Laws Repair-Reuse-Remanufacture Toxicity

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Disinfection byproducts in drinking water and regulatory compliance: A critical review

Xiaomao WANG,Yuqin MAO,Shun TANG,Hongwei YANG,Yuefeng F. XIE

Frontiers of Environmental Science & Engineering 2015, Volume 9, Issue 1, Pages 3-15 doi: 10.1007/s11783-014-0734-1

Abstract: This critical review focuses on the issues associated with DBP regulatory compliance, including methodsPrecursor removal and alternative disinfectants are common practices for DBP regulatory compliance.

Keywords： Disinfection byproducts (DBPs) drinking water standards regulatory compliance alternative disinfection

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Liver cell therapies: cellular sources and grafting strategies

Frontiers of Medicine 2023, Volume 17, Issue 3, Pages 432-457 doi: 10.1007/s11684-023-1002-1

Abstract: development of genetic sequencing technologies, research on the liver’s cellular composition and its regulatory

Keywords： liver regeneration hepatocytes cholangiocytes stem cells organoids regulatory mechanisms transplantation

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METABOLIC AND TRANSCRIPTOME ANALYSIS REVEALS METABOLITE VARIATION AND FLAVONOID REGULATORY NETWORKS IN

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 2,

Abstract: Here, we focus on the seasonal variation in metabolites of fresh tea shoots and their regulatory mechanismThe regulatory pathway was explored by constructing a metabolite correlation network and a weighted gene

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Life-cycle cost analysis of optimal timing of pavement preservation

Zilong WANG,Hao WANG

Frontiers of Structural and Civil Engineering 2017, Volume 11, Issue 1, Pages 17-26 doi: 10.1007/s11709-016-0369-3

Abstract: integrated life-cycle cost analysis (LCCA) model to quantify the impact of pavement preservation on agencyThe traffic loading and the initial IRI value significantly affects life extension and the benefit of agencyThe benefit in VOC is one to two orders greater in magnitude as compared to the benefit in agency costoptimal timing calculated based on VOC is always earlier than the optimal timing calculated based on agency

Keywords： pavement preservation life-cycle cost analysis agency cost vehicle operation cost

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Green Construction of National Speed Skating Oval

Frontiers of Engineering Management 2022, Volume 9, Issue 1, Pages 170-176 doi: 10.1007/s42524-021-0177-x

Keywords： Direct-cooling Ice Making System dynamic high-precision construction measurement green construction National

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Regulatory T Cells and Their Clinical Applications in Antitumor Immunotherapy Review

Feng Xie, Rui Liang, Dan Li, Bin Li

Engineering 2019, Volume 5, Issue 1, Pages 132-139 doi: 10.1016/j.eng.2018.12.002

Abstract: Regulatory T cells (Tregs) are a subgroup of suppressive CD4+ T cells that play a vital role in the maintenance

Keywords： Regulatory T cells Cancer Immunotherapy

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METABOLIC AND TRANSCRIPTOME ANALYSIS REVEALS METABOLITE VARIATION AND FLAVONOID REGULATORY NETWORKS IN

Chen-Kai JIANG, De-Jiang NI, Ming-Zhe YAO, Jian-Qiang MA, Liang CHEN

Frontiers of Agricultural Science and Engineering Pages 215-230 doi: 10.15302/J-FASE-2021382

Keywords： harvest season metabolites tea shoots transcriptomics untargeted metabolomics

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Review on Drug Regulatory Science Promoting COVID-19 Vaccine Development in China Review

Zhiming Huang, Zhihao Fu, Junzhi Wang

Engineering 2022, Volume 10, Issue 3, Pages 127-132 doi: 10.1016/j.eng.2022.01.001

Abstract:

Regulatory science is a discipline that uses comprehensive methods of natural science, social scienceas H1N1 flu, severe acute respiratory syndrome (SARS), and Middle East respiratory syndrome (MERS), regulatoryIn particular, with the support of research on drug regulatory science, vaccines have played a majorFurther, this review highlights how regulatory science has promoted the R&D of Chinese COVID-19 vaccines, with analyses from the aspects of national-level planning, relevant laws and regulations, technical

Keywords： Regulatory science COVID-19 vaccine Vaccine industry

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Achievements of the national malaria control and elimination program in the People’s Republic of China

Frontiers of Medicine 2023, Volume 17, Issue 1, Pages 85-92 doi: 10.1007/s11684-021-0917-7

Abstract: provinces of China since 1950, to assess the changes in malaria epidemic patterns from 1950 to 2019 at nationalthan 130 charts, consisting of introductory maps, thematic maps of malaria epidemic and control at nationalobjectively and directly shows the epidemic history, evolution process, and great achievements of the nationalThe Atlas has important reference value for summing up historical experience in the national malaria

Keywords： malaria transmission control elimination China atlas

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Regulatory issues for genetically modified animals

Perry Bradbury HACKETT

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2, Pages 188-203 doi: 10.15302/J-FASE-2019307

Abstract: Regulatory policies have stagnated due to legal guidelines that could not anticipate the needs and solutionsI propose a new, market-based regulatory model for GM livestock that has both a strong scientific foundation

Keywords： algorithms editing FDA GMO recombinant DNA USDA

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Experience and Inspiration from Construction of United States National Parks and Gateway Communities

Liu Huiliang

Strategic Study of CAE 2016, Volume 18, Issue 5, Pages 100-108 doi: 10.15302/J-SSCAE-2016.05.014

Abstract:

This year is the one-hundredth-year anniversary of the United States National Park Service (US NPSOver the last one hundred years, the national park system of the United States had become an importantnational asset that had played a significant role in stimulating economic development and growth aspaper focuses the discussion on the interdependent relationship between the gateway communities and the nationalThis paper uses Rocky Mountain National Park (RMNP) and the town of Estes Park, RNMP's main gateway

Keywords： US National Park Service gateway communities Rocky Mountain National Park the town of Estes Park